Product Name: Caspase-3 (Pro and Active) Antibody [CAS3836]
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB
Applications: Western blot: 2-4 ug/mlThis antibody will detect the pro form and p17 and p12 active forms of Caspase-3.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: The large subunit domain of human Caspase-3 was used as the immunogen for this monoclonal antibody.
Host Species: Mouse
Purification: Protein G purified monoclonal antibody
Physical State: Liquid
CAS NO.: 849214-04-6
Product: cGAMP
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.5 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Caspase-3 Antibody: CPP32, SCA-1, CPP32B, CPP32, Caspase-3, Apopain, CASP-3
Accession NO.:
Protein Ino:
Official Symbol: CASP3
Geneid: 836
Background: Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. They are often referred to as the executioners of apoptosis. Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. Active caspase-1 and -3 are heterodimers, containing two small and two large subunits. Active Caspase-3 subunits are 17kD (p17) and 12kD (p12). Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. It is activated by Caspases -8, -9 and -10 (initiator caspases) and then effects apoptosis by cleaving targeted cellular proteins.
PubMed ID:http://aac.asm.org/content/43/5/1085.abstract
