Product Name: CX3CL1 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IP, WB
Applications: CX3CL1 antibody can be used for detection of CX3CL1 by Western blot at 0.5 – 2 μg/mL dilution. CX3CL1 is ofen observed migrating at 80 – 100 kDa in SDS-PAGE, presumably due to post-translational modification.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CX3CL1 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human CX3CL1.The immunogen is located within amino acids 20 – 70 of CX3CL1.
Host Species: Rabbit
Purification: CX3CL1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1360053-81-1
Product: AVL-292 (benzenesulfonate)
Buffer: CX3CL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: CX3CL1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CX3CL1 Antibody: NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fractalkine, neurotactin, FKN, A-152E5.2, Fractalkine, C-X3-C motif chemokine 1
Accession NO.: AAB50014
Protein Ino: 1899259
Official Symbol: CX3CL1
Geneid: 6376
Background: CX3CL1 Antibody: Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-α in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
PubMed ID:http://aac.asm.org/content/37/8/1720.abstract
