Product Name: CTLA4 Antibody [2G10]
Species Reactivity: Human
Tested Applications: ELISA, ICC, IF, IHC-P, WB
Applications: CTLA-4 antibody can be used for detection of CTLA-4 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 25 kDa Observed: 32 kDa
Immunogen: CTLA-4 antibody was raised against the extracellular domain of human CTLA-4.
Host Species: Mouse
Purification: CTLA-4 Antibody is supplied as protein A purified IgG1.
Physical State: Liquid
CAS NO.: 138977-28-3
Product: Capsazepine
Buffer: CTLA-4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CTLA-4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: CTLA-4 Antibody: CTL4, cytotoxic T-lymphocyte associated protein 4, CD, GSE, GRD4, ALPS5, CD152, IDDM12, CELIAC3
Accession NO.: NP_005205
Protein Ino:
Official Symbol: CTLA4
Geneid: 1493
Background: The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2). Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3). Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4). CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5).
PubMed ID:http://aac.asm.org/content/37/6/1348.abstract
