Product Name: CREBBP Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: CREBBP antibody can be used for detection of CREBBP by ELISA at 1:312500. CREBBP antibody can be used for detection of CREBBP by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 261 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CREBBP.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 587841-73-4
Product: ZCL278
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store CREBBP antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CREBBP, CBP, KAT3A, RSTS, RTS
Accession NO.: NP_001073315
Protein Ino: 119943102
Official Symbol: CREBBP
Geneid: 1387
Background: CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.
PubMed ID:http://aac.asm.org/content/37/3/453.abstract
