Product Name: CRB2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 105, 129, and 141 kDa Observed: 103, 128 kDa
Immunogen: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2.The immunogen is located within amino acids 460 – 510 of CRB2.
Host Species: Rabbit
Purification: CRB2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1211441-98-3
Product: LEE011
Buffer: CRB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CRB2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CRB2 Antibody: Protein crumbs homolog 2, Crumbs-like protein 2
Accession NO.: NP_775960
Protein Ino: 112420992
Official Symbol: CRB2
Geneid: 286204
Background: CRB2 Antibody: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.
PubMed ID:http://aac.asm.org/content/37/2/349.abstract
