Product Name: CLEC7A Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: CLEC7A antibody can be used for detection of CLEC7A by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 27 kDa Observed: 27 kDa
Immunogen: CLEC7A antibody was raised against a 17 amino acid synthetic peptide near the center of human CLEC7A.The immunogen is located within amino acids 70 – 120 of CLEC7A.
Host Species: Rabbit
Purification: CLEC7A Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 23325-78-2
Product: Cephalexin (monohydrate)
Buffer: CLEC7A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CLEC7A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CLEC7A Antibody: BGR, CANDF4, DECTIN1, CLECSF12, BGR, UNQ539/PRO1082, C-type lectin domain family 7 member A, Beta-glucan receptor, DC-associated C-type lectin 1
Accession NO.: NP_922938
Protein Ino: 37675373
Official Symbol: CLEC7A
Geneid: 64581
Background: CLEC7A Antibody: CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
PubMed ID:http://aac.asm.org/content/36/6/1310.abstract
