Product Name: CLEC4E Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB
Applications: Western blot: 2-5 ug/mlProvided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.
Host Species: Rabbit
Purification: Protein A affinity chromatography
Physical State: Liquid
CAS NO.: 74150-27-9
Product: Pimobendan
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.5 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names:
Accession NO.:
Protein Ino:
Official Symbol: CLEC4E
Geneid: 26253
Background: CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.
PubMed ID:http://aac.asm.org/content/36/6/1284.abstract
