Product Name: CIKS Antibody
Species Reactivity: Human
Tested Applications: ELISA, IF, IHC-P, WB
Applications: CIKS antibody can be used for detection of CIKS by Western blot at 1 μg/mL. A band at approximately 63 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 63 kDa
Immunogen: CIKS antibody was raised against a 15 amino acid peptide near the carboxy terminus of human CIKS.The immunogen is located within the last 50 amino acids of CIKS.
Host Species: Rabbit
Purification: CIKS Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 298-46-4
Product: Carbamazepine
Buffer: CIKS Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: CIKS antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CIKS Antibody: ACT1, CIKS, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, PSORS13, Adapter protein CIKS, Nuclear factor NF-kappa-B activator 1, ACT1
Accession NO.: AF274303
Protein Ino: 10242289
Official Symbol: TRAF3IP2
Geneid: 10758
Background: CIKS Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB associates with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. IκB is phosphorylated by IκB kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-κB activator 1). CIKS directly interacts with IKKγ. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.
PubMed ID:http://aac.asm.org/content/36/3/684.abstract
