Product Name: CENPO Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: CENPO antibody can be used for detection of CENPO by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CENPO antibody was raised against a 16 amino acid synthetic peptide from near the center of human CENPO.The immunogen is located within amino acids 170 – 220 of CENPO.
Host Species: Rabbit
Purification: CENPO Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 63590-64-7
Product: Terazosin
Buffer: CENPO Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CENPO antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CENPO Antibody: CENP-O, MCM21R, ICEN-36, ICEN36, Centromere protein O, Interphase centromere complex protein 36, CENP-O
Accession NO.: NP_077298
Protein Ino: 13236565
Official Symbol: CENPO
Geneid: 79172
Background: CENPO Antibody: Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
PubMed ID:http://aac.asm.org/content/35/11/2238.abstract
