Product Name: CD40 Antibody [HM40-3]
Species Reactivity: Mouse, Rat
Tested Applications: Flow, Func
Applications:
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen:
Host Species: Hamster
Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Physical State: liquid
CAS NO.: 591778-68-6
Product: CP-640186
Buffer: Phosphate-buffered aqueous solution, ph7.2.
Concentration: 1 mg/mL
Storage Conditions: The product should be stored undiluted at 4˚C . Do not freeze.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: IGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, Cd40
Accession NO.:
Protein Ino:
Official Symbol: Cd40
Geneid: 21939
Background: The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.
PubMed ID:http://aac.asm.org/content/34/9/1809.abstract
