Product Name: CCDC98 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IHC-P, WB
Applications: CCDC98 antibody can be used for detection of CCDC98 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CCDC98 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98.The immunogen is located within amino acids 80 – 130 of CCDC98.
Host Species: Rabbit
Purification: CCDC98 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 55985-32-5
Product: Nicardipine
Buffer: CCDC98 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CCDC98 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CCDC98 Antibody: ABRA1, CCDC98, ABRA1, UNQ496/PRO1013, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98
Accession NO.: NP_620775
Protein Ino: 109148531
Official Symbol: FAM175A
Geneid: 84142
Background: CCDC98 Antibody: CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
PubMed ID:http://aac.asm.org/content/43/8/1932.abstract
