Product Name: CAND1 Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC, IP, WB
Applications: CAND1 antibody can be used in ELISA starting at 1:000 – 1:1000, and immunohistochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Amino acids 11-24 of Human CAND1/TIP120A (N-terminal) coupled to KLH.
Host Species: Rabbit
Purification: Delipidation and Defibrination
Physical State: Liquid
CAS NO.: 922731-01-9
Product: Omeprazole D3
Buffer: 0.01% sodium azide.
Concentration:
Storage Conditions: Store CAND1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CAND1, KIAA0829, TBP interacting protein, TBP-interacting protein 120A, TIP120, p120 CAND1, TIP120A
Accession NO.: Q86VP6
Protein Ino: 67460541
Official Symbol: CAND1
Geneid: 55832
Background: CAND1 is also known as TIP120A, and TATA-binding protein-interacting protein 120A. The SCF complex consists of the invariable components Skp1, Cul1, and Rbx1 as well as a variable F-box protein, and functions as an E3 ubiquitin ligase. E3 ubiquitin ligases regulate various physiological processes. CAND1 binds to Cul1 and potentially regulates the SCF complex. CAND1 physically associates with Cul1 in the nucleus and this interaction is mediated by a central region of Cul1 distinct from its binding sites for Skp1 and Rbx1. CAND1 selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 forms a ternary complex with CUL1 and ROC1.
PubMed ID:http://aac.asm.org/content/43/3/639.abstract
