Product Name: BRUCE Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC-P
Applications: BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 534 kDa
Immunogen: BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE.The immunogen is located within amino acids 4760 – 4810 of BRUCE.
Host Species: Rabbit
Purification: BRUCE Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 134-62-3
Product: DEET
Buffer: BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: BRUCE antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BRUCE Antibody: BRUCE, APOLLON, KIAA1289, Baculoviral IAP repeat-containing protein 6, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE
Accession NO.: NP_057336
Protein Ino: 153792694
Official Symbol: BIRC6
Geneid: 57448
Background: BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
PubMed ID:http://aac.asm.org/content/42/5/1105.abstract
