Product Name: ATP2C1 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IF, IHC-P, WB
Applications: ATP2C1 antibody can be used for detection of ATP2C1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: ATP2C1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ATP2C1.The immunogen is located within the last 50 amino acids of ATP2C1.
Host Species: Rabbit
Purification: ATP2C1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 198978-94-8
Product: 5(6)-ROX
Buffer: ATP2C1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ATP2C1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ATP2C1 Antibody: HHD, BCPM, PMR1, SPCA1, hSPCA1, ATP2C1A, KIAA1347, PMR1L, HUSSY-28, Calcium-transporting ATPase type 2C member 1, ATPase 2C1
Accession NO.: NP_001001486
Protein Ino: 312836765
Official Symbol: ATP2C1
Geneid: 27032
Background: ATP2C1 Antibody: ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
PubMed ID:http://aac.asm.org/content/53/7/3147.abstract
