Product Name: ATMIN Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, ICC, IF, WB
Applications: ATMIN antibody can be used for detection of ATMIN by Western blot at 1 – 2 μg/ml. Antibody can also be used for Immunocytochemistry at 5 μg/mL. For Immunoflorescence start at 2.5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 73, 79, 91 kDa Observed: 72 kDa
Immunogen: ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN.The immunogen is located within amino acids 200 – 250 of ATMIN.
Host Species: Rabbit
Purification: ATMIN antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 193620-69-8
Product: TAS-301
Buffer: ATMIN Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ATMIN antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ATMIN Antibody: ASCIZ, ZNF822, KIAA0431, ATM interactor, Zinc finger protein 822, ASCIZ
Accession NO.: NP_056066
Protein Ino: 54792092
Official Symbol: ATMIN
Geneid: 23300
Background: The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).
PubMed ID:http://aac.asm.org/content/53/7/2777.abstract
