Product Name: Caspase 3 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: Western Blot: 1:1000
User Note:
Predicted Molecular Weight: 35 19 17 kDa
Immunogen: Caspase 3 antibody was raised against a peptide sequence around aa.29~33 (S-G-I-S-L) derived from Caspase 3.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 1421693-22-2
Product: CDKI-73
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CPP32, SCA-1, CPP32B, SCFR, Apopain
Accession NO.: NP_004337.2
Protein Ino: 14790119
Official Symbol: CASP3
Geneid: 836
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp-|-Gly-217 bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
PubMed ID:http://aac.asm.org/content/43/5/1277.abstract
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Product Name: Caspase-3 Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC-P
Applications: Caspase-3 antibody can be used for detection of Caspase-3 by immunohistochemistry at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 30 kDa
Immunogen: Caspase-3 antibody was raised against a 17 amino acid synthetic peptide near the center of human Caspase-3.The immunogen is located within amino acids 70 – 120 of Caspase-3.
Host Species: Rabbit
Purification: Caspase-3 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 668467-91-2
Product: LDN-57444
Buffer: Caspase-3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Caspase-3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Caspase-3 Antibody: CPP32, SCA-1, CPP32B, CPP32, Caspase-3, Apopain, CASP-3
Accession NO.: NP_004337
Protein Ino: 14790119
Official Symbol: CASP3
Geneid: 836
Background: Caspase-3 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.
PubMed ID:http://aac.asm.org/content/43/5/1098.abstract