Product Name: IL-33 Antibody [12B3C4]
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IF, IHC-P, WB
Applications: IL-33 antibody can be used for the detection of IL-33 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 30 kDa (recombinant protein) Observed: 30 kDa
Immunogen: Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein.
Host Species: Mouse
Purification: IL-33 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Physical State: Liquid
CAS NO.: 3644-61-9
Product: Mezlocillin (sodium)
Buffer: IL-33 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: IL-33 monoclonal antibody can be stored at -20˚C, stable for one year.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: IL-33 Antibody [12B3C4] : DVS27, IL1F11, NF-HEV, NFEHEV, C9orf26
Accession NO.: NP_254274
Protein Ino: 15559209
Official Symbol: IL33
Geneid: 90865
Background: IL-33 Monoclonal Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1αβ, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.
PubMed ID:http://aac.asm.org/content/26/4/431.abstract
