Product Name: HAVCR2 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:2000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 33 kDa
Immunogen: This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1849590-01-7
Product: EED226
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3
Accession NO.: Q8TDQ0
Protein Ino: 311033536
Official Symbol: HAVCR2
Geneid: 84868
Background: CD4 (MIM 186940)-positive T helper lymphocytes can bedivided into types 1 (Th1) and 2 (Th2) on the basis of theircytokine secretion patterns. Th1 cells and their associatedcytokines are involved in cell-mediated immunity to intracellularpathogens and delayed-type hypersensitivity reactions, whereas Th2cells are involved in the control of extracellular helminthicinfections and the promotion of atopic and allergic diseases. The 2types of cells also cross-regulate the functions of the other. TIM3is a Th1-specific cell surface protein that regulates macrophageactivation and enhances the severity of experimental autoimmuneencephalomyelitis in mice.
PubMed ID:http://aac.asm.org/content/21/2/299.abstract
