Product Name: GITRL Antibody [MGTL 10]
Species Reactivity: Mouse
Tested Applications: ELISA, Flow
Applications: ELISA: (direct and indirect: 1:5,000-1:10,000). Flow Cytometry: (1:1,000). Optimal conditions must be determined individually for each application.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant mouse GITRL.
Host Species: Rat
Purification:
Physical State: Liquid
CAS NO.: 760981-83-7
Enzalutamide
Buffer: Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-inducible TNF-related Ligand; TNFSF18
Accession NO.: Q7TS55
Protein Ino: 81894654
Official Symbol: Tnfsf18
Geneid: 240873
Background: GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis, . ). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
PubMed ID:http://aac.asm.org/content/18/1/50.abstract
