Product Name: GAT-2 Antibody
Species Reactivity: Mouse, Rat
Tested Applications: IHC
Applications: The antibody has been directly tested for reactivity in immunohistochemistry in rat cortex and retinal sections. It is anticipated that the antibody will also work in mouse sections based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 82
Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-2.
Host Species: Rabbit
Purification: Affinity Purified
Physical State: Liquid
CAS NO.: 775304-57-9
product targets : Trk Receptor inhibitors
Buffer: 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Concentration:
Storage Conditions: GAT-2 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: GAT-2, Gabt2, Gat-2, Solute carrier family 6 member 13, GAT-2
Accession NO.: P31646
Protein Ino: 400624
Official Symbol: Slc6a13
Geneid: 171163
Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).
PubMed ID:http://aac.asm.org/content/17/1/24.abstract
