Product Name: Fibulin5 Antibody [3F10A5 / 3F8A12]
Species Reactivity: Human
Tested Applications: ELISA, IHC, WB
Applications: Western Blot:1:500 – 1:2000 IHC(P):1:500 – 1:2000IHC(F):1:500 – 1:2000ELISA:Propose dilution 1:10,000.Determining optimal working dilutions by titration test.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Ni-NTA purified truncated recombinant Fibulin 5 expressed in E. Coli strain BL21 (DE3).
Host Species: Mouse
Purification:
Physical State:
CAS NO.: 946128-88-7
Ro 5126766
Buffer:
Concentration:
Storage Conditions: Fibulin 5 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: DANCE, UNQ184/PRO210, Developmental arteries and neural crest EGF-like protein, FIBL-5, EVEC, UP50, ADCL2, ARMD3, DANCE, ARCL1A
Accession NO.: Q9UBX5
Protein Ino: 12643876
Official Symbol: FBLN5
Geneid: 10516
Background: Fibulin 5(FBLN5), with 448-amino acid protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
PubMed ID:http://aac.asm.org/content/41/2/440.abstract
