Product Name: FLIP Antibody [Dave-2]
Species Reactivity: Human, Mouse
Tested Applications: IP, WB
Applications: Immunoprecipitation: (1-2ug/ml) . Western Blot: (1-5ug/ml) . Optimal conditions must be determined individually for each application.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant human FLIP (aa 1-480).
Host Species: Rat
Purification:
Physical State: Liquid
CAS NO.: 690270-29-2
Balapiravir
Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1
Accession NO.: AAC51622
Protein Ino: 2253679
Official Symbol: CFLAR
Geneid: 8837
Background: FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.
PubMed ID:http://aac.asm.org/content/41/3/702.abstract
