Product Name: DNase II Antibody
Species Reactivity: Human
Tested Applications: ELISA, IF, IHC-P, WB
Applications: DNase II antibody can be used for detection of DNase II expression by Western blot at 0.5 μg/mL. An approximate 40 kDa band can be detected, which represents the pro-enzyme of DNase II. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Aprox: 40 kDa
Immunogen: DNase II antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DNase II.The immunogen is located within the last 50 amino acids of DNase II.
Host Species: Rabbit
Purification: DNase II Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 388082-77-7
Product: Lapatinib (ditosylate)
Buffer: DNase II Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: DNase II antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DNase II Antibody: DNL, DNL2, DNASE2A, Deoxyribonuclease-2-alpha, Acid DNase, DNase II alpha
Accession NO.: AF047016
Protein Ino: 2921838
Official Symbol: DNASE2
Geneid: 1777
Background: DNase II Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus. DNase II causes both chromatin condensation and DNA fragmentation. The genes encoding human, porcine, and murine DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (alpha) and 12 kDa (beta) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation. DNase II is ubiquitously expressed in human tissues.
PubMed ID:http://aac.asm.org/content/38/10/2426.abstract
