Product Name: DC-SIGN Antibody [C209/1781]
Species Reactivity: Human
Tested Applications: Flow, IF, IHC-P, WB
Applications: IF: 1-2 ug/mlFlow Cytometry: 0.5-1 ug/million cells in 0.1mlIHC (FFPE): 0.5-1 ug/ml for 30 min at RTTitering of the DC-SIGN antibody may be required for optimal performance.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: A human partial recombinant protein was used as the immunogen for the DC-SIGN antibody.
Host Species: Mouse
Purification: Protein G affinity chromatography
Physical State: Liquid
CAS NO.: 106730-54-5
Product: Olprinone
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: DC-SIGN Antibody: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 antigen, C-type lectin domain family 4 member L
Accession NO.:
Protein Ino:
Official Symbol: CD209
Geneid: 30835
Background: DC-SIGN / CD209 is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
PubMed ID:http://aac.asm.org/content/38/3/558.abstract
