Product Name: CRYBB3 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 24 kDa
Immunogen: This CRYBB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-207 amino acids from the C-terminal region of human CRYBB3.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 327036-89-5
Product: TDZD-8
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Beta-crystallin B3, Beta-B3 crystallin, Beta-crystallin B3, N-terminally processed, CRYBB3, CRYB3
Accession NO.: P26998
Protein Ino: 311033476
Official Symbol: CRYBB3
Geneid: 1417
Background: Crystallins are separated into two classes:taxon-specific, or enzyme, and ubiquitous. The latter classconstitutes the major proteins of vertebrate eye lens and maintainsthe transparency and refractive index of the lens. Since lenscentral fiber cells lose their nuclei during development, thesecrystallins are made and then retained throughout life, making themextremely stable proteins. Mammalian lens crystallins are dividedinto alpha, beta, and gamma families; beta and gamma crystallinsare also considered as a superfamily. Alpha and beta families arefurther divided into acidic and basic groups. Seven protein regionsexist in crystallins: four homologous motifs, a connecting peptide,and N- and C-terminal extensions. Beta-crystallins, the mostheterogeneous, differ by the presence of the C-terminal extension(present in the basic group, none in the acidic group).Beta-crystallins form aggregates of different sizes and are able toself-associate to form dimers or to form heterodimers with otherbeta-crystallins. This gene, a beta basic group member, is part ofa gene cluster with beta-A4, beta-B1, and beta-B2. [provided byRefSeq].
PubMed ID:http://aac.asm.org/content/37/4/804.abstract
