Product Name: CRTC2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: CRTC2 antibody can be used for detection of CRTC2 by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 67, 76 kDa Observed: 70 kDa
Immunogen: CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2.The immunogen is located within the last 50 amino acids of CRTC2.
Host Species: Rabbit
Purification: CRTC2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 152-11-4
Product: Verapamil (hydrochloride)
Buffer: CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CRTC2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CRTC2 Antibody: TORC2, TORC-2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2
Accession NO.: NP_859066
Protein Ino: 32171215
Official Symbol: CRTC2
Geneid: 200186
Background: CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
PubMed ID:http://aac.asm.org/content/37/4/729.abstract
