Product Name: CD80 Antibody [8G12] (HRP)
Species Reactivity: Human
Tested Applications:
Applications:
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 32 kDa Observed: 50 kDa
Immunogen: CD80 antibody was raised against the extracellular domain of human CD80.
Host Species: Mouse
Purification: CD80 Antibody is supplied as protein A purified IgG2b.
Physical State: Liquid
CAS NO.: 1391054-02-6
Product: Vigabatrin (Hydrochloride)
Buffer: CD80 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CD80 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Monoclonal
Conjugate: HRP
Alternate Names: CD80 Antibody: CD80 molecule, B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1
Accession NO.: NP_005182
Protein Ino: 4885123
Official Symbol: CD80
Geneid: 941
Background: CD80 Antibody: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).
PubMed ID:http://aac.asm.org/content/35/4/756.abstract
