Product Name: CD320 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 29 kDa
Immunogen: This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 52-24-4
Product: Thio-TEPA
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Accession NO.: Q9NPF0
Protein Ino: 74734303
Official Symbol: CD320
Geneid: 51293
Background: The CD320 antigen gene encodes the transcobalamin receptor(TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated byreceptors expressed on the cell surface. Transcobalamin II (TCN2;MIM 613441), a plasma protein secreted by endothelial cells, bindsthe cobalamin absorbed in the distal ileum and carries 10 to 30% oftotal circulating cobalamin. CD320 encodes a transcobalaminreceptor that binds TCN2-cobalamin at the plasma membrane andinternalizes the complex by endocytosis (Quadros et al., 2009[PubMed 18779389]).
PubMed ID:http://aac.asm.org/content/34/7/1336.abstract
