Product Name: CCDC141 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IF, IHC-P, WB
Applications: CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141.The immunogen is located within amino acids 40 – 90 of CCDC141.
Host Species: Rabbit
Purification: CCDC141 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 481-46-9
Product: Ginkgetin
Buffer: CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CCDC141 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CCDC141 Antibody: CAMDI, Coiled-coil domain-containing protein 141
Accession NO.: NP_775919
Protein Ino: 299829223
Official Symbol: CCDC141
Geneid: 285025
Background: CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
PubMed ID:http://aac.asm.org/content/43/7/1638.abstract
