Product Name: ABL1 / 2 (Ab 393 / 429) Antibody
Species Reactivity: Human, Mouse
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 135, 210 kDa
Immunogen: ABL1/2 (Ab-393/429) antibody was raised against a peptide sequence around aa.391~395/427~431 (D-T-Y-T-A) derived from ABL1/2 .
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 5147-00-2
Product: O-Acetylserine
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, MAPKAPK1A, RSK1, ABL
Accession NO.: NP_005148.2 / NP_001129472.1
Protein Ino: 62362414 / 209862772
Official Symbol: ABL1 ABL2
Geneid: 25 / 27
Background: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
PubMed ID:http://aac.asm.org/content/51/12/4525.abstract
