Ptosis can market aggressiveness and poor progThe resistance of tumor cells to apoptosis can market aggressiveness and poor prog nosis in different physiological conditions, which include Aligeron In Vitro hypoxia, nutrient deprivation, and nosis in many physiological situations, such as hypoxia, nutrient deprivation, and an anticancer drug remedy. Hence, the identification of strategies to overcome the reticancer drug therapy. Hence, the identification of tactics to overcome the re sistance of tumor cells to apoptosis will significantly assistance enhance the effectiveness of sistance of tumor cells to apoptosis will drastically aid boost the effectiveness of tumor therapy. Moreover, NDRG2 expression is positively correlated with apoptumor treatment. Additionally, NDRG2 expression is positively correlated with apoptosis tosis induced by metabolic stressors, like oxygen deprivation, glucose deprivation, induced by metabolic stressors, such as oxygen deprivation, glucose deprivation, or each, or both, and anticancer drug remedies. Although mechanisms that regulate NDRG2 and anticancer drug treatments. Despite the fact that mechanisms that regulate NDRG2 gene expres gene expression and NDRG2-mediated improvements of tumor cell apoptosis have already been sion and NDRG2mediated improvements of tumor cell apoptosis have been presented, presented, the molecular mechanisms of these elements are unclear. Even though its functional the molecular mechanisms of those aspects are unclear. Despite the fact that its functional domain is domain is not well known, NDRG2 has recently been reported to interact with kinases or not well known, NDRG2 has not too long ago been reported to interact with kinases or phospha phosphatases (or both). Its potential as an adapter protein that mediates protein rotein tases (or each). Its potential as an adapter protein that mediates protein rotein interac interactions seems to induce antitumor phenotypes in many tumor cells. Within the future, tions seems to induce antitumor phenotypes in several tumor cells. In the future, the the continued discovery of and functional research on proteins that interact with NDRG2 continued discovery of and functional research on proteins that interact with NDRG2 really should be conducted. It is actually expected that tumor remedy methods that account for the needs to be carried out. It is actually anticipated that tumor therapy methods that account for theCells 2021, 10, x 10, 2649 Cells 2021,9 8 of 12 ofexpression pattern of NDRG2 or that regulate NDRG2 expression should raise the expression pattern of NDRG2 or that regulate NDRG2 expression should enhance the ef efficiency of tumor treatments. ficiency of tumor therapies.Figure 5. Overview of NDRG2 function in numerous stimuli-mediated apoptosis. Figure 5. Overview of NDRG2 function in numerous stimulimediated apoptosis.Author Contributions: K.D.K. drafted the manuscript DS44960156 Purity & Documentation outline; K.D.K., G.K., and S.L. conceived the tips and prepared the figures. All authors have study and agreed towards the published version in the ideas and ready the figures. All authors have read and agreed to the published version in the manuscript. manuscript.Funding: This perform was supported by the BioGreen21 Agri-Tech Innovation Plan (SA00016073), Author Contributions: K.D.K. drafted the manuscript outline; K.D.K., G.K., and S.L. conceived theFunding: This function was supported Korea, andBioGreen21 Research Foundation of Korea the Rural Improvement Administration, b.
