S 2021, 26, 2438. https:// doi.org/10.3390/molecules26092438 Academic Editor: Celestino Santos-Buelga Received: 6 March 2021 Accepted: 19 April 2021 Published: 22 AprilAbstract: Polyphenols and omega-3 polyunsaturated fatty acids from fish oils, i.e., eicosapentaenoic and docosahexaenoic acids, are well-recognized nutraceuticals, and their single antioxidant and antiinflammatory properties happen to be demonstrated in various research identified within the literature. It has been reported that the combination of these nutraceuticals can lead to three-fold increases in glutathione peroxidase activity, Caspase 2 Activator custom synthesis two-fold increases in plasma antioxidant capacity, decreases of 5000 in lipid peroxidation, protein carbonylation, and urinary 8-isoprotanes, also as 5000 D4 Receptor Inhibitor Purity & Documentation attenuation of common inflammation biomarkers, among other effects, as in comparison to their person capacities. Therefore, the adequate combination of those bioactive food compounds and their single properties should offer you a powerful tool for the design and style of effectively nutritional interventions for the prevention and palliation of a plethora of human metabolic illnesses, frequently diet-induced, whose etiology and progression are characterized by redox homeostasis disturbances plus a low-grade of chronic inflammation. Nonetheless, the certain mechanisms behind their biological activities, in vivo interaction (both amongst them as well as other food compounds), and their optimal doses and consumption are not well-known yet. For that reason, we overview here the current proof accumulated throughout the final decade concerning the cooperative action among polyphenols and fish oils against diet-related metabolic alterations, focusing on the mechanisms and pathways described and also the effects reported. The final objective would be to give helpful information and facts for techniques for customized nutrition primarily based on these nutraceuticals. Keyword phrases: eicosapentaenoic acid; docosahexaenoic acid; omega-3 polyunsaturated fatty acids; plant bioactives; oxidative stress; inflammation; metabolic problems; nutraceuticals1. Introduction Nutraceuticals, defined as “any substance which is meals or aspect of a food and supply medical or wellness added benefits, which includes the prevention and remedy of disease” , are currently regarded as a viable strategy for the prevention and palliation of many human illnesses, which includes these induced by the consumption of “obesogenic” diets. The widespread consumption of diets higher in saturated fat and sugar and low in polyunsaturated fatty acids (PUFAs) and antioxidants, with each other with a a lot more sedentary life style, have notably elevated the prevalence of metabolic alterations like the socalled Metabolic Syndrome (MetS) . MetS is actually a pathological situation defined by the simultaneous presence of diverse combinations of three or extra in the following metabolic alterations: abdominal obesity, blood hypertension, hyperglycemia, and serum dyslipidemia . It has been estimated that MetS affects more than a billion persons worldwide  and is deemed a threat element for noncommunicable illnesses for instance form two diabetes and cardiovascular illnesses (CVD) . Other principal chronic illnesses promoted by obesity are cancer and neurodegenerative pathologies, both affecting a terrific number of peoplePublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is definitely an open access post distributed und.