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Nts, AOs, that are molecules capable of donating H-atoms to lipid radicals to regenerate them [4,12,13]. The efficiency of the AOs in inhibiting lipid oxidation is generally assessed in terms of the rate of your chemical reaction among the AO along with the lipid radical, which is determined by, amongst other individuals, the effective concentrations with the antioxidant inside the interfacial region of your emulsions [138]. Nevertheless, figuring out concentrations of AOs in the interfaces of emulsions is difficult due to the physical impossibility of separating the interfacial region in the oil and aqueous ones with no disrupting the existing equilibria [19,20]. Our laboratory developed a kinetic system to identify the Nitrocefin MedChemExpress efficient concentrations of antioxidants in emulsions. The approach is based on the reaction with the chemical probe 4-hexadecylbenzenediazonium ion, whose reactive group (-N2 ) is exclusively positioned inside the interfacial area of emulsions together with the antioxidants; see Scheme 3. The experimental final results have been then interpreted on the grounds on the pseudophase kinetic model [19]. The basis on the process has been published, and only a short explanation might be offered here (Section 1.1). Right here, we determined the distribution and efficiencies of p-octyl- and p-tetradecylcoumarates in corn oil-in-water emulsions stabilized with Tween 20. Their chemical structures are given in Scheme 3. We also determined their antioxidant activity inside the very same intact emulsions by monitoring the formation of conjugated dienes with time. Coumaric acid derivatives are of interest for humans because they can lower low density lipoprotein (LDL) peroxidation and lessen the threat of stomach cancer showing anti-mutagenesis, anti-genotoxicity, and anti-microbial activities, inhibiting cellular melanogenesis [213]. On the other hand, their efficiency is, normally, low due to the fact their solubility within the interfacial and oil regions of lipid-based systems is quite low; nevertheless, in someMolecules 2021, 26,4 ofinstances, they will be improved by esterification of their carboxylic group, rising their hydrophobicity [247].Scheme 3. Representation with the oil (O), water (W), and interfacial (I) regions of emulsion droplets, showing the emulsifier Tween 20 along with the place on the reactive probe 16-ArN2 . Antioxidants of moderate hydrophobicity distribute involving the 3 regions, but for the sake of simplicity and clarity, only the distribution of hydrophobic AOs, Share this post on:

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