Product Name :
Rabbit anti-NMNAT1 Polyclonal Antibody(C-Term)
Synonym :
Nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; 2.7.7.1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1; 2.7.7.18; NMNAT1; NMNAT
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This NMNAT1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-232 amino acids from human NMNAT1.
Predicted Reactivity:
Bovine, Mouse
Applications :
WB~~1:2000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Metabolism;Neuroscience;Signal Transduction
Background :
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
UniProt :
Q9HAN9
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Purified Rabbit Polyclonal Antibody (Pab) |Synonym Nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; 2.7.7.1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1; 2.7.7.18; NMNAT1; NMNAT |Host Rabbit |Specificity This NMNAT1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-232 amino acids from human NMNAT1. |Species Reactivity Human |Predicted Reactivity Bovine, Mouse |Applications WB~~1:2000 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Research areas Metabolism;Neuroscience;Signal Transduction |Target |Background Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. |Cellular localization Nucleus |UniProt Q9HAN9 |References |References Schweiger M.,et al.FEBS Lett. 492:95-100(2001).Emanuelli M.,et al.J. Biol. Chem. 276:406-412(2001).Fernando F.S.,et al.Gene 284:23-29(2002).Ota T.,et al.Nat. Genet. 36:40-45(2004).Gregory S.G.,et al.Nature 441:315-321(2006). |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-NMNAT1 Polyclonal Antibody(C-Term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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