Product Name :
CXCR2-IN-1
Description:
CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.
CAS:
1873376-49-8
Molecular Weight:
476.35
Formula:
C19H20Cl2FN3O4S
Chemical Name:
3-4-chloro-2-hydroxy-3-[(1-methylpiperidin-4-yl)sulfonyl]phenyl-1-(2-chloro-3-fluorophenyl)urea
Smiles :
CN1CCC(CC1)S(=O)(=O)C1=C(O)C(=CC=C1Cl)NC(=O)NC1=CC=CC(F)=C1Cl
InChiKey:
BJYOBCUGMDKPBM-UHFFFAOYSA-N
InChi :
InChI=1S/C19H20Cl2FN3O4S/c1-25-9-7-11(8-10-25)30(28,29)18-12(20)5-6-15(17(18)26)24-19(27)23-14-4-2-3-13(22)16(14)21/h2-6,11,26H,7-10H2,1H3,(H2,23,24,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Diclosulam site
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.|Product information|CAS Number: 1873376-49-8|Molecular Weight: 476.Odesivimab Formula 35|Formula: C19H20Cl2FN3O4S|Chemical Name: 3-4-chloro-2-hydroxy-3-[(1-methylpiperidin-4-yl)sulfonyl]phenyl-1-(2-chloro-3-fluorophenyl)urea|Smiles: CN1CCC(CC1)S(=O)(=O)C1=C(O)C(=CC=C1Cl)NC(=O)NC1=CC=CC(F)=C1Cl|InChiKey: BJYOBCUGMDKPBM-UHFFFAOYSA-N|InChi: InChI=1S/C19H20Cl2FN3O4S/c1-25-9-7-11(8-10-25)30(28,29)18-12(20)5-6-15(17(18)26)24-19(27)23-14-4-2-3-13(22)16(14)21/h2-6,11,26H,7-10H2,1H3,(H2,23,24,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5.PMID:34823211 4 mg/mL (11.34 mM; Need ultrasonic and warming).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).|In Vivo:|CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.|Products are for research use only. Not for human use.|
