Product Name: EFHD2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: EFHD2 antibody can be used for detection of EFHD2 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: EFHD2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human EFHD2.The immunogen is located within the first 50 amino acids of EFHD2.
Host Species: Rabbit
Purification: EFHD2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 817204-33-4
Product: PSI-6130
Buffer: EFHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: EFHD2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: EFHD2 Antibody: SWS1, SWS1, EF-hand domain-containing protein D2, Swiprosin-1
Accession NO.: NP_077305
Protein Ino: 20149675
Official Symbol: EFHD2
Geneid: 79180
Background: EFHD2 Antibody: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-κB-activating branch.
PubMed ID:http://aac.asm.org/content/39/5/1182.abstract
