Product Name: BAFF Antibody [2.81]
Species Reactivity: Human
Tested Applications: ELISA, IP
Applications: ELISA: (as a capture antibody). Immunoprecipitation: (1:200).
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: HA-tagged human BAFF.
Host Species: Rat
Purification: >95% (SDS-PAGE)
Physical State: Liquid
CAS NO.: 273727-89-2
Product: ZM39923
Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B
Accession NO.: NP_006564
Protein Ino: 5730097
Official Symbol: TNFSF13B
Geneid: 10673
Background: BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
PubMed ID:http://aac.asm.org/content/53/10/4292.abstract
