Product Name: Aldh3A2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: Aldh3A2 antibody can be used for detection of Aldh3A2 by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Aldh3A2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Aldh3A2.The immunogen is located within the last 50 amino acids of Aldh3A2.
Host Species: Rabbit
Purification: Aldh3A2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1485-00-3
Product: MNS
Buffer: Aldh3A2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Aldh3A2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Aldh3A2 Antibody: SLS, FALDH, ALDH10, Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10
Accession NO.: NP_001026976
Protein Ino: 73466520
Official Symbol: ALDH3A2
Geneid: 224
Background: Aldh3A2 Antibody: Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.
PubMed ID:http://aac.asm.org/content/52/8/2831.abstract
