Product Name: Glycogen synthase (phospho Ser9) Antibody
Species Reactivity: Bovine, Dog, Human, Mouse, Rat, Xenopus, Zebrafish
Tested Applications: WB
Applications: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with human, mouse, chicken, bovine, canine, non-human primate, Zebra fish and Xenopus based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 46
Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser9 of GSK3b.
Host Species: Rabbit
Purification: Affinity Purified
Physical State: Liquid
CAS NO.: 597-12-6
GSK-J4
Buffer: 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Concentration:
Storage Conditions: Glycogen synthase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Factor A, GSK-3 beta
Accession NO.: P18266
Protein Ino: 125374
Official Symbol: Gsk3b
Geneid: 84027
Background: Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that is involved in the regulation of many signaling pathways. To date, 2 isoforms have been identified: GSK3alpha and GSK3beta. Specifically, GSK3beta has been shown to play a key inhibitory role in both the insulin and Wnt signaling pathways (Papkoff and Aikawa 1998). It has been suggested that Ser9 phosphorylation underlies the inhibition of GSK3beta by insulin (Sutherland et al., 1993).
PubMed ID:http://aac.asm.org/content/18/4/645.abstract
