Product Name: Choline Acetyltransferase Antibody
Species Reactivity: Chicken, Goat, Human, Mouse, Rat
Tested Applications: IHC, WB
Applications:
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 70
Immunogen: Native choline acetyltransferase purified from human placenta.
Host Species: Goat
Purification: Affinity Purified
Physical State: Liquid
CAS NO.: 65-86-1
Product: Orotic acid
Buffer: 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Concentration:
Storage Conditions: Choline Acetyltransferase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CMS1A, CMS1A2, CHOACTASE, CHOACTase
Accession NO.: P28329
Protein Ino: 281185509
Official Symbol: CHAT
Geneid: 1103
Background: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
PubMed ID:http://aac.asm.org/content/36/2/291.abstract
