Product Name: CLDN14 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 26 kDa
Immunogen: This CLDN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human CLDN14.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 53902-12-8
Product: Tranilast
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Claudin-14, CLDN14
Accession NO.: O95500
Protein Ino:
Official Symbol: CLDN14
Geneid: 23562
Background: Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. The protein encoded by this gene, amember of the claudin family, is an integral membrane protein and acomponent of tight junction strands. The encoded protein also bindsspecifically to the WW domain of Yes-associated protein. Defects inthis gene are the cause of an autosomal recessive form ofnonsyndromic sensorineural deafness. It is also reported that foursynonymous variants in this gene are associated with kidney stonesand reduced bone mineral density. Several transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
PubMed ID:http://aac.asm.org/content/36/5/1109.abstract
