Product Name: CISD2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 15 kDa Observed: 15 kDa
Immunogen: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.The immunogen is located within amino acids 40 – 90 of CISD2.
Host Species: Rabbit
Purification: CISD2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 68252-28-8
Product: (R)-Oxiracetam
Buffer: CISD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CISD2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CISD2 Antibody: ERIS, WFS2, ZCD2, NAF-1, Miner1, CDGSH2, ERIS, CDGSH iron-sulfur domain-containing protein 2, Endoplasmic reticulum intermembrane small protein
Accession NO.: NP_001008389
Protein Ino: 56605994
Official Symbol: CISD2
Geneid: 493856
Background: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
PubMed ID:http://aac.asm.org/content/36/4/744.abstract
