Product Name: CHUK Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IHC, WB
Applications: CHUK antibody can be used in ELISA starting at 1:10000, Western Blot starting at 1:500 – 1:2000, immunohistochemistry starting at 1:100, and immunofluorescence starting at 1:200 – 1:1000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CHUK antibody was raised against amino acids surrounding Thr 23 of CHUK (Human).
Host Species: Rabbit
Purification: Immunoaffinity Chromatography
Physical State: Liquid
CAS NO.: 87333-19-5
Product: Ramipril
Buffer: PBS, 0.02% sodium azide, 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: CHUK antibody should be stored long term (months) at -80 ˚C and short term (days) at -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CHUK, I-kappa-B kinase alpha, I-kappa-B kinase-alpha, Ikb kinase alpha, IKK-A, IKBKA, IKK1, NFKBIKA, I-kappa-B kinase 1, IkappaB kinase, IKK Alpha, IKK-alpha, IKKA, Transcription factor 16, IkappaBalpha Kinase, IkB kinase alpha subunit, IKK-a kinase, Ikkalpha, TCF-16, TCF16
Accession NO.: O15111
Protein Ino: 317373368
Official Symbol: CHUK
Geneid: 1147
Background: IKKalpha, an IkappaB-type protein kinase, is a member of the multimeric IkappaB kinase complex. This complex, often consisting of IKKalpha/IKKbeta heterodimers plus regulatory IKKgamma subunits, phosphorylates IkappaB proteins, marking them for destruction and thereby allowing activation of NFkappaB and downstream nuclear genes. The constitutively expressed IKKalpha protein contains a N-terminal kinase domain, a central leucine zipper motif, and a C-terminal helix-loop-helix motif. In knockout studies, IKKalpha (-/-) mice died perinatally and displayed a range of developmental defects; thus, IKKalpha is believed to function in development, particularly in development of skin keratinocyte, cornea, and conjunctiva.
PubMed ID:http://aac.asm.org/content/36/3/603.abstract
