Product Name: CENPW Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: CENPW antibody can be used for detection of CENPW by Western blot at 0.5 – 1 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: kDa
Immunogen: CENPW antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CENPW.The immunogen is located within the first 50 amino acids of CENPW.
Host Species: Rabbit
Purification: CENPW Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 50-42-0
Product: Adiphenine (hydrochloride)
Buffer: CENPW Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CENPW antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CENPW Antibody: CUG2, CENP-W, C6orf173, CUG2, Centromere protein W, Cancer-up-regulated gene 2 protein
Accession NO.: NP_001012525
Protein Ino: 60302883
Official Symbol: CENPW
Geneid: 387103
Background: CENPW Antibody: CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
PubMed ID:http://aac.asm.org/content/35/11/2253.abstract
