Product Name: CD70 Antibody [FR70]
Species Reactivity: Mouse
Tested Applications: Flow, Func
Applications:
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen:
Host Species: Rat
Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Physical State: liquid
CAS NO.: 1005491-05-3
Product: Tirasemtiv
Buffer: Phosphate-buffered aqueous solution, ph7.2.
Concentration: 1 mg/mL
Storage Conditions: The product should be stored undiluted at 4˚C . Do not freeze.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Cd27l, CD27LG, Tnfsf7, Cd70
Accession NO.:
Protein Ino:
Official Symbol: Cd70
Geneid: 21948
Background: The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
PubMed ID:http://aac.asm.org/content/35/3/484.abstract
