Product Name: CBL (phospho Tyr674) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 120 kDa
Immunogen: CBL (phospho Tyr674) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y (p)-S-L) derived from Human CBL.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 1173671-63-0
Product: Rhosin
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: C-CBL, CBL2, Proto-oncogene c-Cbl, RNF55,
Accession NO.: NP_005179.2
Protein Ino: 115855
Official Symbol: CBL
Geneid: 867
Background: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
PubMed ID:http://aac.asm.org/content/43/6/1475.abstract