Product Name: CBLC Antibody
Species Reactivity: Human
Tested Applications: ELISA, IF, IHC, IP, WB
Applications: CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CBLC antibody was raised against amino acids 444 – 458 of CBLC (Human).
Host Species: Rabbit
Purification: Immunoaffinity Chromatography
Physical State: Liquid
CAS NO.: 7181-73-9
Product: Bephenium
Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Concentration:
Storage Conditions: Store CBLC antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CBLC, CBL-3, CBL3, RNF57, SH3-binding protein CBL-C, SH3-binding protein CBL-3, CBL-c, CBL-SL, RING finger protein 57
Accession NO.: Q9ULV8
Protein Ino: 125987803
Official Symbol: CBLC
Geneid: 23624
Background: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.
PubMed ID:http://aac.asm.org/content/43/6/1525.abstract
